{"id":5557,"date":"2024-01-25T16:16:28","date_gmt":"2024-01-25T08:16:28","guid":{"rendered":"http:\/\/www.sstkbiotech.com\/?p=5557"},"modified":"2024-01-25T16:16:28","modified_gmt":"2024-01-25T08:16:28","slug":"%e4%bd%93%e5%8f%af%e9%97%aetk1%e5%ba%94%e7%94%a8%e6%96%b0%e6%bd%9c%e5%8a%9b%ef%bc%81%e9%a6%96%e4%b8%aatk1%e7%94%a8%e4%ba%8e%e8%82%ba%e7%bb%93%e8%8a%823%e5%b9%b4%e8%82%ba%e7%99%8c%e5%8f%91%e7%94%9f","status":"publish","type":"post","link":"http:\/\/www.sstkbiotech.com\/?p=5557","title":{"rendered":"\u4f53\u53ef\u95eeTK1\u5e94\u7528\u65b0\u6f5c\u529b\uff01\u9996\u4e2aTK1\u7528\u4e8e\u80ba\u7ed3\u82823\u5e74\u80ba\u764c\u53d1\u751f\u98ce\u9669\u9884\u6d4b\u6a21\u578b\u53d1\u8868"},"content":{"rendered":"
\u3010\u7f16\u8005\u6ce8\u3011\u672c\u7814\u7a76\u6240\u91c7\u7528TK1\u6280\u672f\uff0c\u5747\u6307\u534e\u745e\u540c\u5eb7\u516c\u53f8\u4e13\u5229\u539f\u7814\u7684\u4f53\u53ef\u95eeTK1\u6280\u672f\uff0c\u4e0e\u5176\u4ed6\u975e\u4f53\u53ef\u95ee\u54c1\u724c\u7684TK1\u6280\u672f\u65e0\u5173\u3002<\/span><\/h5>\n

\"\"<\/h4>\n

\u7531\u6df1\u5733\u5e02\u827e\u4f26\u65af\u6587\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u6240\u80f8\u82f7\u6fc0\u9176\uff08TK1\uff09\u7814\u7a76\u56e2\u961f\u8054\u5408\u4e2d\u56fd\u79d1\u5b66\u6280\u672f\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u7814\u7a76\u56e2\u961f\u4e0e\u4e2d\u56fd\u5065\u5eb7\u4fc3\u8fdb\u57fa\u91d1\u4f1a\u5171\u540c\u5b8c\u6210\u7684\u7814\u7a76\u8bba\u6587\u300aA Novel Model Using Serum Thymidine Kinase 1 and Low-dose Computed Tomography Parameters to Predict Three-year Lung Cancer Risk in People with Pulmonary Nodules: A Retrospective Study\u300b\u4e8e2024\u5e741\u67081\u65e5\u5728JCR\u4e8c\u533a\u671f\u520aJournal of Cancer\uff08IF=3.9\uff09\u9996\u53d1\u3002<\/h4>\n

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\u540c\u65f6\uff0c\u56e2\u961f\u6839\u636e\u8be5\u6a21\u578b\u5f00\u53d1\u4e86\u4e00\u4e2a\u7f51\u9875\u5e94\u7528\u7a0b\u5e8f\uff0c\u53ef\u65b9\u4fbf\u5730\u4e3a\u80ba\u7ed3\u8282\u60a3\u8005\u63d0\u4f9b\u80ba\u764c\u98ce\u9669\u8bc4\u4f30\uff0c\u586b\u8865\u4e86\u76ee\u524dTK1\u764c\u75c7\u98ce\u9669\u91cf\u5316\u5de5\u5177\u7814\u7a76\u548c\u5e94\u7528\u7684\u7a7a\u767d\u3002<\/h4>\n

\u7814\u7a76\u8bba\u6587\u5177\u4f53\u4ecb\u7ecd\u5982\u4e0b\u3002<\/h4>\n

\u4e00\u3001\u7814\u7a76\u80cc\u666f<\/strong><\/span><\/h3>\n

\u5355\u72ec\u4f7f\u7528LDCT\u96be\u4ee5\u51c6\u786e\u8bc4\u4f30\u80ba\u7ed3\u8282\u7684\u764c\u53d8\u98ce\u9669\uff0c2\u5e74\u968f\u8bbf\u65f6\u5047\u9633\u6027\u7387\u9ad8\u8fbe23.3%\u3002\u8fd9\u53ef\u80fd\u5bfc\u81f4\u4e0d\u5fc5\u8981\u7684\u8f90\u5c04\u66b4\u9732\u3001\u4fb5\u5165\u6027\u6d3b\u68c0\u3001\u7ecf\u6d4e\u6210\u672c\u548c\u60a3\u8005\u7126\u8651\u3002\u672c\u7814\u7a76\u65e8\u5728\u5f00\u53d1\u4e00\u4e2a\u53ef\u5e94\u7528\u4e8e\u5927\u89c4\u6a21\u80ba\u764c\u7b5b\u67e5\u4eba\u7fa4\u7684\u6a21\u578b\uff0c\u4ee5\u534f\u52a9\u51c6\u786e\u9884\u6d4b\u80ba\u7ed3\u8282\u4e09\u5e74\u5185\u8fdb\u5c55\u4e3a\u80ba\u764c\u7684\u98ce\u9669\u3002<\/h4>\n

\u4e8c\u3001\u7814\u7a76\u65b9\u6cd5<\/strong><\/span><\/h3>\n

\u8be5\u7814\u7a76\u7eb3\u51656841\u540d\u5e74\u9f84>30\u5c81\u3001\u6709LDCT\u68c0\u51fa\u80ba\u7ed3\u8282\u3001\u4f46\u6ca1\u6709\u764c\u75c7\u75c5\u53f2\u6216\u764c\u75c7\u8bca\u65ad\u7684\u7814\u7a76\u5bf9\u8c61\uff0c\u7ec4\u6210\u56de\u987e\u6027\u961f\u5217\u3002\u7814\u7a76\u7684\u7ed3\u5c40\u4e8b\u4ef6\u4e3a\u5728\u9996\u6b21\u53d1\u73b0\u80ba\u7ed3\u8282\u540e\u4e09\u5e74\u5185\u65b0\u53d1\u7684\u80ba\u764c\u4e34\u5e8a\u8bca\u65ad\u3002\u91c7\u7528\u57fa\u4e8e\u6297\u4ebaTK1-IGY\u6297\u4f53\u7684\u589e\u5f3a\u5316\u5b66\u53d1\u5149\u6cd5\u68c0\u6d4b\u8840\u6e05TK1\u6d53\u5ea6\uff08STK1p\uff09\uff08\u8bd5\u5242\u76d2\u53ca\u4eea\u5668\u6765\u81ea\u534e\u745e\u540c\u5eb7\u751f\u7269\u6280\u672f\uff08\u6df1\u5733\uff09\u6709\u9650\u516c\u53f8\uff09\u3002\u4f7f\u7528\u673a\u5668\u5b66\u4e60LASSO\u7b97\u6cd5\u7b5b\u900914\u9879\u5019\u9009\u9884\u6d4b\u56e0\u7d20\u5e76\u62df\u5408\u903b\u8f91\u56de\u5f52\u6a21\u578b\u3002\u901a\u8fc7\u53d7\u8bd5\u8005\u5de5\u4f5c\u7279\u5f81\u66f2\u7ebf\uff08ROC\uff09\u4e0b\u9762\u79ef\uff08AUC\uff09\u3001\u6821\u51c6\u5ea6\u548c\u51c0\u6548\u76ca\u5bf9\u6a21\u578b\u8fdb\u884c\u5185\u90e8\u9a8c\u8bc1\u3002\u57fa\u4e8e\u6a21\u578b\u5f00\u53d1\u4e00\u4e2a\u53ef\u89c6\u5316\u7f51\u9875\u5e94\u7528\u7a0b\u5e8f\u3002<\/h4>\n

\u4e09\u3001\u7ed3\u679c<\/strong><\/span><\/h3>\n

\u7ed3\u679c\u663e\u793a\u7814\u7a76\u5bf9\u8c61\u4e2d\u76843\u5e74\u80ba\u764c\u53d1\u75c5\u7387\u4e3a0.79% (n=52)\u3002LASSO\u7b97\u6cd5\u9009\u62e9\u7684\u9884\u6d4b\u56e0\u7d20\u4e3a\u8840\u6e05TK1\u6d53\u5ea6\uff08STK1p\uff09\u548c3\u4e2aLDCT\u53c2\u6570\uff08\u7ed3\u8282\u5927\u5c0f\u3001\u7c7b\u578b\u548c\u6570\u91cf\uff09\u3002\u6a21\u578b\u7684AUC\u4e3a0.91(95%\u7f6e\u4fe1\u533a\u95f4\uff08CI): 0.86, 0.96)\u3002\u8be5\u6a21\u578b\u5728\u5185\u90e8\u9a8c\u8bc1(AUC: 0.90(0.84, 0.96))\u548c\u4e9a\u7ec4\u4e2d(AUC=0.69-0.93)\u5177\u6709\u826f\u597d\u7684\u9884\u6d4b\u6548\u679c\u3002\u91c7\u7528Youden\u6307\u6570\u9009\u62e9\u7684\u6a21\u578b\u98ce\u9669\u6700\u4f18\u9608\u503c\u4e3a2%\uff0c\u7075\u654f\u5ea6\u548c\u7279\u5f02\u5ea6\u5206\u522b\u4e3a84.60%(\u5047\u9634\u6027\u7387=15.40%)\u548c92.30%(\u5047\u9633\u6027\u7387=7.70%)\uff0c\u4f18\u4e8e\u5355\u72ec\u4f7f\u7528LDCT\u3002\u53733\u5e74\u80ba\u764c\u53d1\u75c5\u6982\u7387\u22652%\u7684\u7814\u7a76\u5bf9\u8c61\u53ef\u88ab\u5b9a\u4e49\u4e3a\u9ad8\u98ce\u9669\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u68c0\u67e5\u5982PET-CT\u6216\u5bc6\u5207\u968f\u8bbf\u3002\u9ad8\u98ce\u9669\u7ec43\u5e74\u80ba\u764c\u98ce\u9669\u663e\u8457\u9ad8\u4e8e\u4f4e\u98ce\u9669\u7ec4(\u4f18\u52bf\u6bd4(OR)= 66.03 (95% CI: 30.49, 162.98))\u3002<\/h4>\n

\"\"<\/h4>\n

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\"\"<\/h4>\n

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\u56db\u3001\u7ed3\u8bba<\/strong><\/span><\/h3>\n

\u8054\u5408STK1p\u548cLDCT\u53c2\u6570\u7684\u65b0\u6a21\u578b\u53ef\u4ee5\u534f\u52a9\u51c6\u786e\u9884\u6d4b\u65e0\u764c\u75c7\u53f2\u7684\u80ba\u7ed3\u8282\u60a3\u80053\u5e74\u5185\u53d1\u751f\u80ba\u764c\u7684\u6982\u7387\u3002\u7136\u800c\uff0c\u76ee\u524d\u4e9f\u9700\u524d\u77bb\u6027\u961f\u5217\u7814\u7a76\u5bf9\u6a21\u578b\u7684\u5e94\u7528\u6548\u679c\u8fdb\u884c\u5916\u90e8\u9a8c\u8bc1\uff0c\u5e76\u7eb3\u5165\u66f4\u591a\u80ba\u764c\u9884\u6d4b\u98ce\u9669\u56e0\u7d20\u5982\u751f\u6d3b\u65b9\u5f0f\u7b49\u4ee5\u4f18\u5316\u6a21\u578b\u6548\u80fd\u3002<\/h4>\n

\u540e\u8bb0<\/strong><\/span><\/h3>\n

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\u4f5c\u8005\uff1a\u6c6a\u6d77\u4e1c\u3001\u9ec4\u6f47\u9633<\/h4>\n

\u5355\u4f4d\uff1a\u6df1\u5733\u5e02\u827e\u4f26\u65af\u6587\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u6240<\/h4>\n

\u8054\u7cfb\u4eba\uff1a\u6c6a\u6d77\u4e1c \u6240\u957f<\/h4>\n

\u8054\u7cfb\u65b9\u5f0f\uff1aoffice@sstkmed.org<\/h4>\n

\u7f51\u5740\uff1ahttp:\/\/sstkmed.org\/<\/h4>\n","protected":false},"excerpt":{"rendered":"

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